Keir Starmer has announced his resignation as British PM and leader of the Labour Party.
He said every decision he has made in office has been about "putting the country I love first".
Andy Burnham - who could replace the PM - will be in Westminster today to be sworn in as MP for Makerfield, after winning the by-election last week.
deVere Group CEO, Nigel Green, said: “Financial markets have already begun to react.
“Sterling weakened against the dollar following the announcement, while gilt yields remain elevated after months of political uncertainty and concerns about the UK’s fiscal outlook.
“Investors are now turning their attention to the identity of Starmer’s successor and what it could mean for taxation, borrowing and economic policy.”